Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191068 | 0.87 | LMNA (0.44) | ALDH1A1OPRM1OPRK1LMNAUTS2R | |
| SCHEMBL5192869 | 0.86 | OPRK1 (0.46) | OPRM1OPRK1LMNAMEN1KMT2A | |
| SCHEMBL5192480 | 0.81 | SIGMAR1 (0.48) | SMN1; SMN2HPGDGAAMAPTALDH1A1 | |
| SCHEMBL5278583 | 0.81 | LMNA (0.44) | GFERALDH1A1LMNAKDM4E | |
| SCHEMBL5190010 | 0.80 | POLB (0.60) | SMN1; SMN2HPGDGAAALDH1A1MEN1 | |
| SCHEMBL5190760 | 0.80 | ALDH1A1 (0.49) | SMN1; SMN2GFERMAPTALDH1A1MEN1 | |
| SCHEMBL5193163 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1LMNARAB9AMEN1 | |
| SCHEMBL5190692 | 0.78 | ALDH1A1 (0.48) | ALDH1A1OPRM1OPRK1LMNAUTS2R | |
| SCHEMBL5207365 | 0.77 | LMNA (0.41) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5210351 | 0.76 | FAAH (0.46) | MAPTLMNARAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |