Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PDE5A | O76074 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190656 | 0.93 | KMT2A (0.53) | ALDH1A1KMT2AMAPK1POLBRECQL | |
| SCHEMBL5192869 | 0.85 | OPRK1 (0.46) | KMT2AMAPK1TDP1MEN1 | |
| SCHEMBL5191068 | 0.84 | LMNA (0.44) | ALDH1A1KMT2AMAPK1POLBMEN1 | |
| SCHEMBL5278583 | 0.84 | LMNA (0.44) | ALDH1A1MAPK1POLBGFER | |
| SCHEMBL5193992 | 0.80 | SMN1; SMN2 (0.48) | ALDH1A1KMT2ATDP1MEN1MAPT | |
| SCHEMBL5193163 | 0.77 | SMN1; SMN2 (0.44) | ALDH1A1KMT2AMAPK1POLBMEN1 | |
| SCHEMBL5213600 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KMT2APOLBMEN1EPHX1 | |
| SCHEMBL5207365 | 0.75 | LMNA (0.41) | ALDH1A1KMT2AMAPK1POLBMEN1 | |
| SCHEMBL5190692 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KMT2AMAPK1 | |
| SCHEMBL5190763 | 0.73 | RXFP1 (0.46) | ALDH1A1KMT2APDE5ARXFP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |