Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 3/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190932 | 0.81 | EPHX2 (0.52) | MAPTALDH1A1MEN1HPGDALOX12 | |
| SCHEMBL5193944 | 0.76 | LMNA (0.48) | LMNAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL5195925 | 0.75 | KMT2A (0.58) | ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL13882047 | 0.73 | P2RX7 (0.61) | LMNAMAPTALDH1A1MEN1ALPL | |
| SCHEMBL5192841 | 0.73 | RAB9A (0.65) | LMNAALDH1A1HPGDHTTKMT2A | |
| SCHEMBL5191103 | 0.73 | RAB9A (0.51) | LMNAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL5191447 | 0.72 | HPGD (0.57) | ALDH1A1MEN1HPGDHTTKMT2A | |
| SCHEMBL12354898 | 0.72 | ALDH1A1 (0.74) | ERCC1ERCC4LMNAMAPTALDH1A1 | |
| SCHEMBL5297611 | 0.72 | HTR6 (0.46) | — | |
| SCHEMBL2260332 | 0.72 | CHRM1 (0.61) | HTTP2RX7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |