Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11849277 | 0.82 | ALDH1A1 (0.44) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL5201507 | 0.77 | ALDH1A1 (0.40) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL11705831 | 0.77 | ALDH1A1 (0.50) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL7329332 | 0.77 | MEN1 (0.42) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL7329911 | 0.77 | ALDH1A1 (0.40) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL14336359 | 0.77 | RECQL (0.42) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL30046397 | 0.76 | HTR1A (0.51) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL11548784 | 0.76 | HTR1A (0.51) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL30817653 | 0.75 | ALDH1A1 (0.73) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL7479419 | 0.75 | ALDH1A1 (0.73) | KDM4EALDH1A1GAAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | claimed |
| US-20060194830-A1 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. | 2006-08-31 | — | — | US | claimed |
| US-7057047-B2 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2006-06-06 | — | — | US | claimed |
| EP-1490363-B1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2-YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | INDEVUS PHARMACEUTICALS INC (US) | 2006-01-25 | — | — | EP | claimed |
| US-20050288322-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2005-12-29 | — | — | US | claimed |
| EP-1490363-A1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2-YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | Warner-Lambert Company LLC (US) | 2004-12-29 | — | — | EP | claimed |
| US-20030191315-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | ENDO PHARMACEUTICALS INC. | 2003-10-09 | — | — | US | claimed |
| WO-2003082870-A1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | claimed |
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-20060194830-A1 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. | 2006-08-31 | — | — | US | disclosed |
| US-7057047-B2 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1490363-B1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2-YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | INDEVUS PHARMACEUTICALS INC (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050288322-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2005-12-29 | — | — | US | disclosed |
| US-6949653-B2 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1490363-A1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2-YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | Warner-Lambert Company LLC (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20030191315-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | ENDO PHARMACEUTICALS INC. | 2003-10-09 | — | — | US | disclosed |
| WO-2003082870-A1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288322-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | NT5C3B, NT5C, CYP2J2 | KDM4E 3157/4885ALDH1A1 135/4885GAA 3316/4885 |
| US-20030191315-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | NT5C, NT5C3B, UGT8 | KDM4E 3343/4885ALDH1A1 238/4885GAA 3060/4885 |
| US-20060194830-A1 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | NT5C, NT5C3B, UGT8 | KDM4E 3333/4885ALDH1A1 272/4885GAA 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.