Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11755046 | 0.85 | NPC1 (0.47) | MEN1KMT2AALPLALDH1A1KDM4E | |
| SCHEMBL7329652 | 0.81 | MEN1 (0.31) | MEN1KMT2AALDH1A1KDM4EHTT | |
| SCHEMBL7329911 | 0.81 | ALDH1A1 (0.40) | MEN1KMT2AALPLALDH1A1KDM4E | |
| SCHEMBL14336359 | 0.81 | RECQL (0.42) | MEN1KMT2AALPLALDH1A1KDM4E | |
| SCHEMBL5201507 | 0.81 | ALDH1A1 (0.40) | MEN1KMT2AALPLALDH1A1KDM4E | |
| SCHEMBL11489729 | 0.80 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL11608638 | 0.80 | JUN (0.38) | ALDH1A1POLBCYP3A4NFKB1MAPT | |
| SCHEMBL11484272 | 0.79 | LMNA (0.39) | — | |
| SCHEMBL5200701 | 0.77 | KDM4E (0.54) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL10472405 | 0.77 | POLB (0.37) | MEN1KMT2AALPLALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-5102890-A | Anxiolytic agents | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |
| US-4960779-A | Pyrrole derivatives, and pharmaceutical compositions which contain them and pharmacological methods of use | RHONE-POULENC SANTE (FR) | 1990-10-02 | — | — | US | disclosed |
| US-4016274-A | TRANQUILIZERS AND ANTICONVULSANT AGENTS | RHONE-POULENC S.A. (FR) | 1977-04-05 | — | — | US | disclosed |