Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329332 | 0.81 | MEN1 (0.42) | ALDH1A1KDM4EGAAPOLBHTT | |
| SCHEMBL14336359 | 0.81 | RECQL (0.42) | ALDH1A1KDM4EGAAPOLBALPL | |
| SCHEMBL7329911 | 0.81 | ALDH1A1 (0.40) | ALDH1A1KDM4EGAAPOLBHTT | |
| SCHEMBL11486646 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KMT2A | |
| SCHEMBL11486146 | 0.79 | CA12 (0.40) | CA12CA1CA2CA9 | |
| SCHEMBL5200701 | 0.77 | KDM4E (0.54) | ALDH1A1KDM4EGAAPOLBHTT | |
| SCHEMBL10472405 | 0.77 | POLB (0.37) | ALDH1A1KDM4EGAAPOLBNR1H3 | |
| SCHEMBL11548784 | 0.73 | HTR1A (0.51) | ALDH1A1KDM4EGAAPOLBHTT | |
| SCHEMBL30046397 | 0.73 | HTR1A (0.51) | ALDH1A1KDM4EGAAPOLBHTT | |
| SCHEMBL12195998 | 0.71 | POLB (0.47) | POLBNR1H3SCN2AHTTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304158-B2 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-20060194830-A1 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | INDEVUS PHARMACEUTICALS, INC. | 2006-08-31 | — | — | US | disclosed |
| US-7057047-B2 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1490363-B1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2-YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | INDEVUS PHARMACEUTICALS INC (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050288322-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2005-12-29 | — | — | US | disclosed |
| US-6949653-B2 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | INDEVUS PHARMACEUTICALS, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1490363-A1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2-YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | Warner-Lambert Company LLC (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20030191315-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | ENDO PHARMACEUTICALS INC. | 2003-10-09 | — | — | US | disclosed |
| WO-2003082870-A1 | METHODS OF PREPARATION OF THE 2-(7-CHLORO-1,8-NAPHTHYRIDINE-2YL)-3-(5-METHYL-2-OXO-HEXYL)-1-ISOINDOLINONE | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288322-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone | NT5C3B, NT5C, CYP2J2 | ALDH1A1 135/4885KDM4E 3157/4885GAA 3316/4885 |
| US-20030191315-A1 | Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone | NT5C, NT5C3B, UGT8 | ALDH1A1 238/4885KDM4E 3343/4885GAA 3060/4885 |
| US-20060194830-A1 | Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone) | NT5C, NT5C3B, UGT8 | ALDH1A1 272/4885KDM4E 3333/4885GAA 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.