Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | FASN | P49327 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205864 | 0.82 | RORC (0.46) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5202338 | 0.81 | GFER (0.47) | ALDH1A1NPC1RAB9AATMPOLB | |
| SCHEMBL5705162 | 0.80 | RORC (0.51) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5937364 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KMT2APOLBRORCLMNA | |
| SCHEMBL4858050 | 0.77 | RAB9A (0.62) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4855807 | 0.76 | KDM4E (0.48) | ALDH1A1TSHRMAPK1RORCLMNA | |
| SCHEMBL4859672 | 0.76 | HSD11B1 (0.52) | POLB | |
| SCHEMBL5203757 | 0.75 | NPC1 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL5203887 | 0.75 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ARAB9APOLB | |
| SCHEMBL5201910 | 0.74 | NPC1 (0.42) | MEN1KMT2ANPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |