Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203268 | 0.87 | GAA (0.48) | GAAALDH1A1HTTKDM4ECCR5 | |
| SCHEMBL5201722 | 0.82 | HTR2B (0.53) | RORCALDH1A1USP2HPGDMAPK1 | |
| SCHEMBL4859672 | 0.80 | HSD11B1 (0.52) | HSD11B1SPRDRD2DRD3 | |
| SCHEMBL5203887 | 0.79 | ALDH1A1 (0.52) | GAAALDH1A1KDM4EHSD11B1SPR | |
| SCHEMBL5202338 | 0.78 | GFER (0.47) | RORCALDH1A1HSD11B1USP2SPR | |
| SCHEMBL3065644 | 0.76 | HSD11B1 (0.68) | ALDH1A1HTTKDM4EHSD11B1HPGDS | |
| SCHEMBL5937364 | 0.75 | ALDH1A1 (0.57) | RORCALDH1A1KDM4EUSP2SPR | |
| SCHEMBL5705162 | 0.75 | RORC (0.51) | RORCALDH1A1KDM4EUSP2SPR | |
| SCHEMBL14730730 | 0.73 | RECQL (0.59) | GAAALDH1A1HTTCHRNB2CHRNB4 | |
| SCHEMBL14197788 | 0.73 | RECQL (0.59) | GAAALDH1A1HTTCHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |