Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859672 | 0.87 | HSD11B1 (0.52) | HSD11B1SPRTPSAB1GFERPROKR1 | |
| SCHEMBL5203557 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KMT2AHSD11B1LMNAMEN1 | |
| SCHEMBL5205864 | 0.79 | RORC (0.46) | ALDH1A1KMT2AHSD11B1MEN1KDM4E | |
| SCHEMBL5201936 | 0.79 | SPR (0.39) | ALDH1A1KMT2AHSD11B1LMNAMEN1 | |
| SCHEMBL5202338 | 0.76 | GFER (0.47) | ALDH1A1HSD11B1SPRTPSAB1GFER | |
| SCHEMBL5201722 | 0.75 | HTR2B (0.53) | ALDH1A1KMT2ALMNAMEN1RAB9A | |
| SCHEMBL5937364 | 0.72 | ALDH1A1 (0.57) | ALDH1A1KMT2ALMNAKDM4ESPR | |
| SCHEMBL5705162 | 0.72 | RORC (0.51) | ALDH1A1KMT2ALMNAMEN1KDM4E | |
| SCHEMBL29944450 | 0.72 | KMT2A (0.73) | ALDH1A1KMT2ALMNAMEN1KDM4E | |
| SCHEMBL4858050 | 0.70 | RAB9A (0.62) | ALDH1A1KMT2ALMNAMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |