Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 7/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859112 | 0.84 | RORC (0.47) | GFERRORCHTR6TPSAB1SPR | |
| SCHEMBL5201722 | 0.81 | HTR2B (0.53) | RORCUSP2ALDH1A1POLBNPC1 | |
| SCHEMBL5202345 | 0.81 | HTR6 (0.41) | GFERRORCHTR6USP2ALDH1A1 | |
| SCHEMBL5205864 | 0.78 | RORC (0.46) | RORCSPRUSP2ALDH1A1HSD11B1 | |
| SCHEMBL5937364 | 0.78 | ALDH1A1 (0.57) | RORCTPSAB1SPRUSP2ALDH1A1 | |
| SCHEMBL5705162 | 0.78 | RORC (0.51) | RORCTPSAB1SPRUSP2ALDH1A1 | |
| SCHEMBL4859672 | 0.77 | HSD11B1 (0.52) | GFERTPSAB1SPRHSD11B1HCRTR1 | |
| SCHEMBL5203887 | 0.76 | ALDH1A1 (0.52) | GFERTPSAB1SPRALDH1A1HSD11B1 | |
| SCHEMBL4858050 | 0.76 | RAB9A (0.62) | RORCALDH1A1POLBNPC1RAB9A | |
| SCHEMBL18701720 | 0.75 | RORC (0.49) | RORCTPSAB1SPRUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |