Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206419 | 0.88 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1SLC2A1 | |
| SCHEMBL5203757 | 0.88 | NPC1 (0.57) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1NPC1 | |
| SCHEMBL5202510 | 0.79 | HSD11B1 (0.55) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1KMT2A | |
| SCHEMBL4859740 | 0.79 | HTR2A (0.46) | TPSAB1CNR1HRH2 | |
| SCHEMBL5204533 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1NPC1 | |
| SCHEMBL5202168 | 0.79 | PROKR1 (0.47) | ALDH1A1SMN1; SMN2TPSAB1NPC1RAB9A | |
| SCHEMBL4862667 | 0.78 | TSHR (0.47) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1KMT2A | |
| SCHEMBL5202100 | 0.77 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1KMT2A | |
| SCHEMBL5204500 | 0.76 | TPSAB1 (0.47) | ALDH1A1SMN1; SMN2TPSAB1KMT2ACNR1 | |
| SCHEMBL5203268 | 0.74 | GAA (0.48) | ALDH1A1SMN1; SMN2HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368470-B2 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2008-05-06 | — | — | US | disclosed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | OPRD1, OPRK1, TPH1 | ALDH1A1 755/4885SMN1; SMN2 2439/4885HSD11B1 1144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.