Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.47 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4860093 | 0.88 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1HSD11B1TPSAB1SLC2A1 | |
| SCHEMBL5203757 | 0.86 | NPC1 (0.57) | SMN1; SMN2ALDH1A1HSD11B1TPSAB1SLC2A1 | |
| SCHEMBL5202510 | 0.83 | HSD11B1 (0.55) | SMN1; SMN2ALDH1A1HSD11B1TPSAB1KMT2A | |
| SCHEMBL5202100 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1HSD11B1TPSAB1KMT2A | |
| SCHEMBL5202168 | 0.80 | PROKR1 (0.47) | SMN1; SMN2ALDH1A1TPSAB1SLC2A1KMT2A | |
| SCHEMBL5204500 | 0.80 | TPSAB1 (0.47) | SMN1; SMN2ALDH1A1TPSAB1KMT2AHRH2 | |
| SCHEMBL4859715 | 0.79 | HCRTR1 (0.41) | SMN1; SMN2ALDH1A1TPSAB1SLC2A1KMT2A | |
| SCHEMBL5204533 | 0.78 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HSD11B1TPSAB1KMT2A | |
| SCHEMBL4854486 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HSD11B1KMT2AHRH2MEN1 | |
| SCHEMBL4862667 | 0.78 | TSHR (0.47) | SMN1; SMN2ALDH1A1HSD11B1TPSAB1UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |