Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203887 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2ALMNAMEN1KDM4E | |
| SCHEMBL5206944 | 0.73 | RAB9A (0.55) | ALDH1A1KMT2ALMNAMEN1KDM4E | |
| SCHEMBL5202510 | 0.73 | HSD11B1 (0.55) | ALDH1A1KMT2AHSD11B1HRH2PROKR1 | |
| SCHEMBL4859672 | 0.73 | HSD11B1 (0.52) | HSD11B1PROKR1 | |
| SCHEMBL5205671 | 0.73 | MAPT (0.47) | ALDH1A1KMT2ALMNAMEN1KDM4E | |
| SCHEMBL5491834 | 0.72 | MEN1 (0.32) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5202100 | 0.71 | ALDH1A1 (0.51) | ALDH1A1KMT2AHSD11B1FNTAFNTB | |
| SCHEMBL5203268 | 0.70 | GAA (0.48) | ALDH1A1KMT2AKDM4EHSD11B1GAA | |
| SCHEMBL5206637 | 0.70 | LMNA (0.44) | KMT2ALMNAMEN1HSD11B1L3MBTL1 | |
| SCHEMBL4854486 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1KDM4EHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |