Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858050 | 0.82 | RAB9A (0.62) | RAB9AMAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL4857604 | 0.78 | MAPT (0.53) | RAB9AMAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL5202233 | 0.78 | HRH2 (0.41) | RAB9AMAPTNPC1HPGDALDH1A1 | |
| SCHEMBL5205671 | 0.74 | MAPT (0.47) | RAB9AMAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL5203557 | 0.73 | ALDH1A1 (0.50) | RAB9AALDH1A1LMNAGAAMEN1 | |
| SCHEMBL4849757 | 0.73 | HRH2 (0.47) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4860169 | 0.70 | MAPT (0.40) | RAB9AMAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL7301194 | 0.69 | RAB9A (0.68) | RAB9AMAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL7301191 | 0.69 | RAB9A (0.68) | RAB9AMAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL4858356 | 0.68 | CREBBP (0.42) | ALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |