Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 5/20 | 0.52 |
| ▸ | ST14 | Q9Y5Y6 | 5/20 | 0.52 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487349 | 0.80 | ADAM17 (0.36) | HPNST14HGFACKMT2AHTT | |
| SCHEMBL5203062 | 0.74 | HCRTR1 (0.49) | ALDH1A1HTR6LMNAPOLBTHRB | |
| SCHEMBL4851454 | 0.71 | HTR6 (0.43) | ALDH1A1HTR6LMNAPOLBTHRB | |
| SCHEMBL5205820 | 0.70 | HRH2 (0.42) | KMT2ALMNA | |
| SCHEMBL4860552 | 0.70 | HRH2 (0.46) | KMT2AALDH1A1LMNA | |
| SCHEMBL4854486 | 0.70 | ALDH1A1 (0.46) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL4851493 | 0.70 | MEN1 (0.45) | KMT2AMEN1HTR6 | |
| SCHEMBL22500546 | 0.70 | KMT2A (0.70) | HPNST14HGFACKMT2AALDH1A1 | |
| SCHEMBL22500544 | 0.70 | KMT2A (0.70) | HPNST14HGFACKMT2AALDH1A1 | |
| SCHEMBL5206637 | 0.70 | LMNA (0.44) | KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |