Sugi Predict

Sugi Predict / Compounds / SCHEMBL520332

SCHEMBL520332

SCHEMBL520332

CS(=O)(=O)c1ccc(B(O)O)cc1F

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ENPP2 Q13822 1/20 0.50
▸ CCR2 P41597 2/20 0.40
▸ PIK3CD O00329 1/20 0.37
▸ PIK3CA P42336 1/20 0.37
▸ PIK3CB P42338 1/20 0.37
▸ PIK3CG P48736 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ CA2 P00918 2/20 0.34
▸ LPL P06858 1/20 0.34
▸ LIPG Q9Y5X9 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ GRM4 Q14833 1/20 0.34
▸ GPR119 Q8TDV5 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19214301 0.85 ENPP2 (0.50) ENPP2CCR2CA2LPLLIPG
SCHEMBL26613496 0.81 CA2 (0.41) ENPP2CA2CA1ALDH1A1
SCHEMBL23852735 0.79 L3MBTL1 (0.53) ENPP2L3MBTL1CA2LPLLIPG
SCHEMBL20399722 0.78 ENPP2 (0.50) ENPP2CCR2PIK3CDPIK3CAPIK3CB
SCHEMBL30449750 0.77 ENPP2 (0.46) ENPP2CCR2PIK3CDPIK3CAPIK3CB
SCHEMBL16183499 0.77 ENPP2 (0.46) ENPP2CCR2PIK3CDPIK3CAPIK3CB
SCHEMBL4010773 0.76 ENPP2 (0.52) ENPP2L3MBTL1CA2LPLLIPG
SCHEMBL30311154 0.75 ENPP2 (0.47) ENPP2L3MBTL1CA2ALDH1A1
SCHEMBL23884760 0.75 ENPP2 (0.47) ENPP2L3MBTL1CA2ALDH1A1
SCHEMBL25301879 0.75 ENPP2 (0.47) ENPP2CA2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12378250-B2 Tricyclic compound as IRAK4 inhibitor KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-08-05 — — US disclosed
EP-3885348-B1 NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR KOREA RES INST CHEMICAL TECH (KR) 2025-02-12 — — EP disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 — — US disclosed
US-11318119-B2 HIV protease inhibitors GILEAD SCIENCES, INC. (US) 2022-05-03 — — US disclosed
EP-3955921-A1 2-IMINO-5-OXO-IMIDAZOLIDINE INHIBITORS OF HIV PROTEASE GILEAD SCIENCES, INC. (US) 2022-02-23 — — EP disclosed
US-20220009933-A1 NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2022-01-13 — — US disclosed
EP-3885348-A1 NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR Korea Research Institute of Chemical Technology (KR) 2021-09-29 — — EP disclosed
US-20200345699-A1 HIV PROTEASE INHIBITORS GILEAD SCIENCES, INC. 2020-11-05 — — US disclosed
WO-2020214716-A1 2-IMINO-5-OXO-IMIDAZOLIDINE INHIBITORS OF HIV PROTEASE GILEAD SCIENCES, INC. (US) 2020-10-22 — — WO disclosed
US-10722495-B2 Cyanoindazole compounds and uses thereof INCYTE CORPORATION (US) 2020-07-28 — — US disclosed
WO-2010071885-A1 PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS CEPHALON, INC. (US) 2010-06-24 — — WO disclosed
EP-1530470-B9 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP LILLY CO ELI (US) 2010-04-07 — — EP disclosed
US-7585977-B2 Selective estrogen receptor modulators containing a phenylsulfonyl group ELI LILLY AND COMPANY (US) 2009-09-08 — — US disclosed
EP-1530470-B1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP LILLY CO ELI (US) 2009-06-10 — — EP disclosed
US-20080214612-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP DALLY ROBERT DEAN 2008-09-04 — — US disclosed
US-7399867-B2 Selective estrogen receptor modulators containing a phenylsulfonyl group ELI LILLY AND COMPANY (US) 2008-07-15 — — US disclosed
EP-1782810-A2 Selective estrogen receptor modulators containing a phenylsulfonyl group Eli Lilly & Company (US) 2007-05-09 — — EP disclosed
US-20060183736-A1 Selective estrogen receptor modulators containing a phenylsulfonyl group ELILILLY AND COMPANY 2006-08-17 — — US disclosed
EP-1530470-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP ELI LILLY AND COMPANY (US) 2005-05-18 — — EP disclosed
WO-2004009086-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP ELI LILLY AND COMPANY (US) 2004-01-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200345699-A1 HIV PROTEASE INHIBITORS ACE, PRSS1, TMPRSS2 ENPP2 1520/4885CCR2 1705/4885PIK3CD 1371/4885
US-10722495-B2 Cyanoindazole compounds and uses thereof PCK1, PDXK, PHKG1 ENPP2 2144/4885CCR2 4573/4885PIK3CD 2690/4885
US-12378250-B2 Tricyclic compound as IRAK4 inhibitor IRAK4, IRAK1, IRAK2 ENPP2 2259/4885CCR2 1180/4885PIK3CD 109/4885
US-11318119-B2 HIV protease inhibitors ACE, PRSS1, TMPRSS2 ENPP2 1520/4885CCR2 1705/4885PIK3CD 1371/4885
US-20220009933-A1 NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR IRAK4, IRAK1, IRAK2 ENPP2 2202/4885CCR2 1188/4885PIK3CD 102/4885
US-20080214612-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP GPER1, ESR2, ESR1 ENPP2 1066/4885CCR2 3887/4885PIK3CD 2807/4885
US-20060183736-A1 Selective estrogen receptor modulators containing a phenylsulfonyl group GPER1, ESR2, ESR1 ENPP2 1066/4885CCR2 3887/4885PIK3CD 2807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.