SCHEMBL5203956

SCHEMBL5203956

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)C(O)C2(F)F)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PDE4D Q08499 1/20 0.53
▸ PDE3A Q14432 1/20 0.53
▸ SLC29A1 Q99808 1/20 0.53
▸ ADORA3 P0DMS8 1/20 0.52
▸ HPGD P15428 2/20 0.50
▸ HINT1 P49773 1/20 0.48
▸ NT5E P21589 1/20 0.48
▸ ADORA2A P29274 1/20 0.48
▸ PNP P00491 2/20 0.46
▸ TK1 P04183 1/20 0.46
▸ GSK3A P49840 2/20 0.45
▸ RPS6KA3 P51812 2/20 0.45
▸ MAPK14 Q16539 2/20 0.45
▸ POLB P06746 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL313652 1.00 PDE4D (0.53) PDE4DPDE3ASLC29A1ADORA3HPGD
Phosphoric Acid SCHEMBL21465104 0.96 NT5E (0.51) PDE4DPDE3ASLC29A1ADORA3HPGD
SCHEMBL546453 0.91 ADORA3 (0.51) PDE3AADORA3HPGDHINT1NT5E
SCHEMBL4844756 0.91 ADORA3 (0.51) PDE3AADORA3HPGDHINT1NT5E
SCHEMBL25380147 0.90 ADORA2A (0.51) ADORA3HPGDHINT1NT5EADORA2A
SCHEMBL19813683 0.90 ADORA2A (0.51) ADORA3HPGDHINT1NT5EADORA2A
SCHEMBL20991026 0.90 ADORA2A (0.51) ADORA3HPGDHINT1NT5EADORA2A
SCHEMBL471141 0.90 ADORA2A (0.51) ADORA3HPGDHINT1NT5EADORA2A
SCHEMBL13929032 0.90 ADORA2A (0.51) ADORA3HPGDHINT1NT5EADORA2A
SCHEMBL465582 0.90 ADORA2A (0.51) ADORA3HPGDHINT1NT5EADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 535 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1819718-A1 DIFLUORONUCLEOSIDES AND PROCESS FOR PREPARATION THEREOF Sicor Inc. (US) 2007-08-22 — — EP claimed
US-20060173174-A1 Difluoronucleosides and process for preparation thereof SICOR, INC. 2006-08-03 — — US claimed
WO-2006063105-A1 DIFLUORONUCLEOSIDES AND PROCESS FOR PREPARATION THEREOF SICOR INC. (US) 2006-06-15 — — WO claimed
EP-4746905-A1 RSV VACCINE Astrazeneca AB (SE) 2026-05-27 — — EP disclosed
WO-2026106956-A1 DISULFIDE-STABILIZED NOROVIRUS VIRUS-LIKE PARTICLE DESIGN MERCK SHARP & DOHME LLC (US) 2026-05-21 — — WO disclosed
US-12629412-B2 Betacoronavirus mRNA vaccines MODERNATX, INC. (US) 2026-05-19 — — US disclosed
US-20260130985-A1 NUCLEIC ACID-BASED UNIVERSAL VACCINE AND METHODS OF USE THEREOF ADVANCED RNA VACCINE ARV TECH INC (US) 2026-05-14 — — US disclosed
US-12622960-B2 Varicella zoster virus (VZV) vaccine MODERNATX, INC. (US) 2026-05-12 — — US disclosed
US-20260108595-A1 BETACORONAVIRUS mRNA VACCINES MODERNATX, INC. (US) 2026-04-23 — — US disclosed
EP-4727955-A1 CYSTEINE-SUBSTITUTED RSV-F PROTEINS GlaxoSmithKline Biologicals S.A. (BE) 2026-04-22 — — EP disclosed
EP-3458081-B1 POLYNUCLEOTIDES ENCODING CITRIN FOR THE TREATMENT OF CITRULLINEMIA TYPE 2 MODERNATX INC (US) 2026-04-15 — — EP disclosed
WO-2015089511-A2 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-06-18 — — WO disclosed
WO-2015085318-A2 TARGETED ADAPTIVE VACCINES MODERNA THERAPEUTICS, INC. (US) 2015-06-11 — — WO disclosed
WO-2015058069-A1 COMPOSITIONS AND METHODS FOR TOLERIZING CELLULAR SYSTEMS MODERNA THERAPEUTICS, INC. (US) 2015-04-23 — — WO disclosed
WO-2015051214-A1 POLYNUCLEOTIDES ENCODING LOW DENSITY LIPOPROTEIN RECEPTOR MODERNA THERAPEUTICS, INC. (US) 2015-04-09 — — WO disclosed
WO-2015038892-A1 POLYNUCLEOTIDE COMPOSITIONS CONTAINING AMINO ACIDS MODERNA THERAPEUTICS, INC. (US) 2015-03-19 — — WO disclosed
WO-2014093924-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2014-06-19 — — WO disclosed
EP-1819718-A1 DIFLUORONUCLEOSIDES AND PROCESS FOR PREPARATION THEREOF Sicor Inc. (US) 2007-08-22 — — EP disclosed
US-20060173174-A1 Difluoronucleosides and process for preparation thereof SICOR, INC. 2006-08-03 — — US disclosed
WO-2006063105-A1 DIFLUORONUCLEOSIDES AND PROCESS FOR PREPARATION THEREOF SICOR INC. (US) 2006-06-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12629412-B2 Betacoronavirus mRNA vaccines RNMT, RNGTT, METTL16 PDE4D 243/4885PDE3A 1044/4885SLC29A1 442/4885
US-20060173174-A1 Difluoronucleosides and process for preparation thereof DUT, NUDT1, DPYD PDE4D 1971/4885PDE3A 3246/4885SLC29A1 57/4885
US-20260108595-A1 BETACORONAVIRUS mRNA VACCINES RNMT, METTL16, NSUN2 PDE4D 2437/4885PDE3A 3528/4885SLC29A1 934/4885
US-12622960-B2 Varicella zoster virus (VZV) vaccine NSUN2, RNMT, RNGTT PDE4D 3216/4885PDE3A 4081/4885SLC29A1 927/4885
US-20260130985-A1 NUCLEIC ACID-BASED UNIVERSAL VACCINE AND METHODS OF USE THEREOF UPF1, NSUN2, CD4 PDE4D 4236/4885PDE3A 4816/4885SLC29A1 685/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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