Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.41 |
| ▸ | ITGAV | P06756 | 12/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048231 | 0.93 | ITGB3 (0.45) | ITGB3ITGAVBCHEITGA2BITGB5 | |
| SCHEMBL5203532 | 0.86 | ITGB3 (0.34) | ITGB3ITGAVITGA2BELANEKDM4E | |
| SCHEMBL5207016 | 0.84 | ITGB1 (0.42) | ITGB3ITGAVITGA2BITGB5KDM4E | |
| SCHEMBL14431257 | 0.84 | ITGB1 (0.42) | ITGB3ITGAVITGA2BITGB5KDM4E | |
| SCHEMBL14431792 | 0.84 | BCHE (0.37) | ITGB3ITGAVBCHEITGA2BITGB5 | |
| SCHEMBL5206753 | 0.82 | ALOX15 (0.39) | ITGB3ITGAVKDM4E | |
| SCHEMBL6505393 | 0.82 | ITGB3 (0.42) | ITGB3ITGAVBCHETRPC3TRPC4 | |
| SCHEMBL5205119 | 0.80 | ITGB3 (0.38) | ITGB3ITGAVELANEKDM4E | |
| SCHEMBL5210309 | 0.80 | TYR (0.41) | ITGB3ITGAVITGA2BELANEKDM4E | |
| SCHEMBL14431276 | 0.79 | ITGB3 (0.39) | ITGB3ITGAVITGA2BITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | claimed |
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1124824-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026212-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-05-11 | — | — | WO | disclosed |