Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205119 | 0.88 | ITGB3 (0.38) | TYRITGB3ITGAVKDM4ELMNA | |
| SCHEMBL5206753 | 0.87 | ALOX15 (0.39) | TYRITGB3ITGAVKDM4ELMNA | |
| SCHEMBL5208511 | 0.83 | ITGB3 (0.37) | TYRITGB3ITGAVKDM4ELMNA | |
| SCHEMBL5207016 | 0.82 | ITGB1 (0.42) | TYRITGB3ITGAVKDM4ELMNA | |
| SCHEMBL14431257 | 0.82 | ITGB1 (0.42) | TYRITGB3ITGAVKDM4ELMNA | |
| SCHEMBL6495736 | 0.82 | ITGB3 (0.44) | TYRITGB3ITGAVITGA2BPPARG | |
| SCHEMBL6498071 | 0.81 | ITGB3 (0.44) | TYRITGB3ITGAVMEN1KMT2A | |
| SCHEMBL3052420 | 0.80 | ITGB3 (0.44) | TYRITGB3ITGAVITGA2BPPARG | |
| SCHEMBL5204539 | 0.80 | ITGB3 (0.41) | ITGB3ITGAVKDM4EKMT2AITGA2B | |
| SCHEMBL5203532 | 0.79 | ITGB3 (0.34) | TYRITGB3ITGAVKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |