Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 10/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 8/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.39 |
| ▸ | ITGAV | P06756 | 8/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.35 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431257 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGAVMDM4 | |
| SCHEMBL14431255 | 0.93 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGAVMDM4 | |
| SCHEMBL3048694 | 0.93 | ITGB1 (0.50) | ITGB1ITGA5ITGB3ITGAVMDM4 | |
| SCHEMBL5203532 | 0.86 | ITGB3 (0.34) | ITGB3ITGAVITGA2BKDM4ELMNA | |
| SCHEMBL5206753 | 0.85 | ALOX15 (0.39) | ITGB3ITGAVKDM4ELMNAHPGD | |
| SCHEMBL5204539 | 0.84 | ITGB3 (0.41) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL5205119 | 0.83 | ITGB3 (0.38) | ITGB3ITGAVKDM4ELMNAHPGD | |
| SCHEMBL5210309 | 0.82 | TYR (0.41) | ITGB3ITGAVITGA2BKDM4ELMNA | |
| SCHEMBL14431254 | 0.82 | MAPT (0.32) | ITGB1ITGA5ITGB3ITGAVKDM4E | |
| SCHEMBL5207840 | 0.82 | MAPT (0.32) | ITGB1ITGA5ITGB3ITGAVKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |