Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495736 | 0.92 | ITGB3 (0.44) | ITGB3ITGAVALOX15TYRCTSK | |
| SCHEMBL5206753 | 0.91 | ALOX15 (0.39) | ITGB3ITGAVALOX15KDM4ELMNA | |
| SCHEMBL5210309 | 0.88 | TYR (0.41) | ITGB3ITGAVALOX15KDM4ELMNA | |
| SCHEMBL5208511 | 0.87 | ITGB3 (0.37) | ITGB3ITGAVALOX15KDM4ELMNA | |
| SCHEMBL5207016 | 0.83 | ITGB1 (0.42) | ITGB3ITGAVKDM4ELMNAHPGD | |
| SCHEMBL14431257 | 0.83 | ITGB1 (0.42) | ITGB3ITGAVKDM4ELMNAHPGD | |
| SCHEMBL6498071 | 0.82 | ITGB3 (0.44) | ITGB3ITGAVALOX15TYRSTS | |
| SCHEMBL5203532 | 0.82 | ITGB3 (0.34) | ITGB3ITGAVALOX15KDM4ELMNA | |
| SCHEMBL3052420 | 0.81 | ITGB3 (0.44) | ITGB3ITGAVALOX15TYRSTS | |
| SCHEMBL5204539 | 0.80 | ITGB3 (0.41) | ITGB3ITGAVKDM4EELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |