Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175984 | 0.89 | LTA4H (0.55) | LTA4H | |
| SCHEMBL5173897 | 0.85 | OPRM1 (0.48) | SIGMAR1OPRM1DRD4KCNH2 | |
| SCHEMBL5176444 | 0.81 | SIGMAR1 (0.58) | SIGMAR1DRD4LTA4HKCNH2CXCR3 | |
| SCHEMBL5174667 | 0.80 | SIGMAR1 (0.65) | SIGMAR1DRD4LTA4HKCNH2CXCR3 | |
| SCHEMBL5174319 | 0.79 | SIGMAR1 (0.64) | SIGMAR1DRD4LTA4HKCNH2CXCR3 | |
| SCHEMBL5174634 | 0.74 | LTA4H (0.65) | SIGMAR1LTA4H | |
| SCHEMBL5652249 | 0.74 | RAB9A (0.62) | — | |
| SCHEMBL5175714 | 0.74 | LTA4H (0.64) | SIGMAR1DRD4LTA4H | |
| SCHEMBL5176107 | 0.73 | HTR1A (0.54) | LTA4H | |
| SCHEMBL10648926 | 0.73 | SIGMAR1 (0.80) | SIGMAR1OPRM1DRD4KCNH2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189012-A | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-28 | — | — | CN | claimed |
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | claimed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | claimed |
| CN-101189012-A | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-28 | — | — | CN | disclosed |
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | SIGMAR1 3624/4885OPRM1 1658/4885DRD4 3772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.