Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | GPR88 | Q9GZN0 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206255 | 0.78 | MEN1 (0.41) | — | |
| SCHEMBL4829855 | 0.78 | CNR1 (0.52) | — | |
| SCHEMBL5200515 | 0.77 | MGLL (0.44) | ALDH1A1 | |
| SCHEMBL5262774 | 0.76 | SLC6A9 (0.54) | — | |
| SCHEMBL5205796 | 0.76 | HPGD (0.46) | ALDH1A1 | |
| SCHEMBL31332669 | 0.74 | LMNA (0.53) | SIGMAR1ALDH1A1HDAC4GPR88 | |
| SCHEMBL4689271 | 0.73 | RAB9A (0.48) | ALDH1A1 | |
| SCHEMBL5479926 | 0.73 | PRMT5 (0.42) | ALDH1A1 | |
| SCHEMBL31332685 | 0.73 | LMNA (0.57) | SIGMAR1ALDH1A1HDAC4GPR88 | |
| SCHEMBL31332765 | 0.73 | LMNA (0.49) | SIGMAR1ALDH1A1HDAC4GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |