Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAC1 | P63000 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857534 | 0.89 | DRD4 (0.40) | HRH2DRD4POLBMAPTSMN1; SMN2 | |
| SCHEMBL5203876 | 0.68 | ALDH1A1 (0.39) | HRH2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL4859877 | 0.67 | HRH2 (0.42) | HRH2HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL4859724 | 0.63 | SMO (0.46) | HRH2HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL5203814 | 0.62 | SMO (0.51) | HRH2HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL5347587 | 0.62 | CYP1A2 (0.50) | HRH2HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL5202142 | 0.61 | LMNA (0.50) | HRH2HTR6SMODRD2HDAC3 | |
| SCHEMBL5205062 | 0.61 | SMO (0.46) | HRH2SMOHDAC3HDAC1HDAC2 | |
| SCHEMBL5202270 | 0.61 | MAPT (0.43) | DRD4MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL5350498 | 0.61 | HRH2 (0.76) | HRH2HTR2AHTR2CHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |