Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861849 | 0.87 | KDM1A (0.46) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL1087235 | 0.69 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1KMT2AMEN1 | |
| SCHEMBL5202510 | 0.68 | HSD11B1 (0.55) | SMN1; SMN2ALDH1A1KMT2AHTTHRH2 | |
| SCHEMBL5204238 | 0.67 | HSD11B1 (0.47) | SMN1; SMN2ALDH1A1RAB9AMAPTNPSR1 | |
| SCHEMBL5206733 | 0.66 | SCD5 (0.47) | SMN1; SMN2TSHRLMNAALDH1A1RAB9A | |
| SCHEMBL5201634 | 0.66 | SLC2A1 (0.47) | SMN1; SMN2LMNAALDH1A1NPSR1KMT2A | |
| SCHEMBL5202100 | 0.66 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1KMT2AHRH2 | |
| SCHEMBL5202596 | 0.66 | ALDH1A1 (0.47) | TSHRLMNAALDH1A1KDM4ESLC2A1 | |
| SCHEMBL5202048 | 0.65 | SLC2A1 (0.44) | SMN1; SMN2LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL5206419 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |