Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.54 |
| ▸ | LTA4H | P09960 | 6/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MDH2 | P40926 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207887 | 0.87 | KDM4E (0.60) | MEN1KMT2APOLBKDM4EMAPT | |
| SCHEMBL5210851 | 0.83 | MAPT (0.60) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL5211955 | 0.82 | LTA4H (0.48) | TRPM8LTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL5209045 | 0.81 | CDK2 (0.49) | MEN1KMT2APOLBMAPTSMN1; SMN2 | |
| SCHEMBL5210504 | 0.81 | TSHR (0.56) | POLBKDM4EMAPTSLC6A4SMN1; SMN2 | |
| SCHEMBL5207800 | 0.79 | ICMT (0.51) | MEN1KMT2AKDM4E | |
| SCHEMBL5213599 | 0.79 | ICMT (0.61) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL853597 | 0.78 | LTA4H (0.64) | PPARGPPARDPPARATRPM8LTA4H | |
| SCHEMBL30176255 | 0.78 | LTA4H (0.64) | PPARGPPARDPPARATRPM8LTA4H | |
| SCHEMBL4490807 | 0.78 | PPARG (0.71) | PPARGPPARDPPARATRPM8LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | claimed |
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | disclosed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-20040092569-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2004-05-13 | — | — | US | disclosed |
| EP-1343757-A1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050031-A1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092569-A1 | Indole derivatives | PTGER4, PTGER1, TRPV4 | PPARG 1182/4885PPARD 876/4885PPARA 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.