SCHEMBL23701732

SCHEMBL23701732

COC(=O)Cc1c[nH]c2ccc(-c3ccccc3OC)cc12

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ICMT O60725 6/20 0.79
CDK4 P11802 1/20 0.51
CCND1 P24385 1/20 0.51
LMNA P02545 2/20 0.51
USP2 O75604 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
CLK4 Q9HAZ1 1/20 0.51
KMT2A Q03164 2/20 0.48
KDM4E B2RXH2 1/20 0.48
PKM P14618 1/20 0.46
IDO1 P14902 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
CNR2 P34972 1/20 0.45
MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23701762 0.89 ICMT (0.81) ICMTCDK4CCND1LMNAUSP2
SCHEMBL30098548 0.84 NR4A2 (0.62) ICMTLMNACYP2C9KMT2AKDM4E
SCHEMBL23718989 0.84 NR4A2 (0.62) ICMTLMNACYP2C9KMT2AKDM4E
SCHEMBL6923141 0.82 ICMT (0.67) ICMTCDK4CCND1LMNAUSP2
SCHEMBL23701740 0.81 ICMT (0.55) ICMTLMNAKMT2AKDM4EPKM
SCHEMBL31127579 0.80 ICMT (0.63) ICMTLMNAALDH1A1MAPTTRPV1
SCHEMBL23701799 0.80 ICMT (0.62) ICMTCDK4CCND1LMNAUSP2
SCHEMBL5213599 0.79 ICMT (0.61) ICMTCDK4CCND1LMNAUSP2
SCHEMBL2083266 0.78 ALDH1A1 (0.51) ICMTLMNACYP1A2CYP3A4CYP2D6
SCHEMBL24445971 0.78 ICMT (0.56) ICMTLMNACYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12150447-B2 Plant growth regulator UNIVERSITY OF WASHINGTON (US) 2024-11-26 US disclosed
US-20210235697-A1 PLANT GROWTH REGULATOR UNIVERSITY OF WASHINGTON (US) 2021-08-05 US disclosed
US-20210235697-A1 PLANT GROWTH REGULATOR UNIVERSITY OF WASHINGTON (US) 2021-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210235697-A1 PLANT GROWTH REGULATOR ING2, GHRHR, MYB ICMT 1658/4885CDK4 773/4885CCND1 311/4885
US-12150447-B2 Plant growth regulator ING2, GHRHR, MYB ICMT 1658/4885CDK4 773/4885CCND1 311/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.