Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068362 | 0.83 | ALDH1A1 (0.60) | HPGDLMNAGAAL3MBTL1ROCK2 | |
| SCHEMBL31680569 | 0.74 | KMT2A (0.89) | HPGDLMNAGAAL3MBTL1KMT2A | |
| SCHEMBL11901003 | 0.74 | KMT2A (0.89) | HPGDLMNAGAAL3MBTL1KMT2A | |
| SCHEMBL17686276 | 0.73 | HPGD (1.00) | HPGDLMNAGAAL3MBTL1KMT2A | |
| SCHEMBL4923374 | 0.73 | KMT2A (0.51) | HPGDLMNAGAAL3MBTL1KMT2A | |
| SCHEMBL17439944 | 0.72 | ROCK2 (1.00) | HPGDLMNAGAAL3MBTL1ROCK2 | |
| SCHEMBL27687948 | 0.72 | LMNA (0.55) | HPGDLMNAGAAL3MBTL1KMT2A | |
| SCHEMBL28076489 | 0.71 | HDAC6 (0.68) | HPGDLMNAROCK2ROCK1KDM4E | |
| SCHEMBL11486711 | 0.70 | CHRNB2 (0.58) | HPGDLMNAGAAL3MBTL1ROCK2 | |
| SCHEMBL5216669 | 0.70 | POLB (0.37) | HPGDGAAKMT2AALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763303-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDES AND DERIVATIVES THEREOF | Bayer CropScience Aktiengesellschaft (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006000333-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDES AND DERIVATIVES THEREOF | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-01-05 | — | — | WO | disclosed |