Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228824 | 0.90 | ICMT (0.40) | DHODHNR3C1TP53SMN1; SMN2TSHR | |
| SCHEMBL5226613 | 0.84 | SMO (0.40) | DHODHNR3C1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL5229296 | 0.83 | HSD17B10 (0.44) | TP53SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL5226619 | 0.82 | NPBWR1 (0.47) | TP53SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL5227284 | 0.82 | CLK4 (0.41) | TP53SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL5224673 | 0.82 | SMO (0.40) | DHODHNR3C1ALDH1A1PIK3R1PIK3CA | |
| SCHEMBL5227418 | 0.82 | PTGS1 (0.38) | NR3C1TP53SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5226500 | 0.80 | PTGS1 (0.36) | NR3C1TP53SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5224744 | 0.80 | HTR1A (0.38) | DHODHNR3C1TSHRALDH1A1HPGD | |
| SCHEMBL5229287 | 0.78 | EGFR (0.40) | DHODHALDH1A1MEN1KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |