Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | SMO | Q99835 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230174 | 0.92 | DRD4 (0.46) | DRD4DRD3DRD2SMOALDH1A1 | |
| SCHEMBL5230607 | 0.89 | DRD4 (0.46) | DRD4DRD3DRD2SMOALDH1A1 | |
| SCHEMBL5227774 | 0.88 | DRD3 (0.45) | DRD4DRD3DRD2SMOALDH1A1 | |
| SCHEMBL5226907 | 0.86 | DRD4 (0.43) | DRD4DRD3DRD2SMOALDH1A1 | |
| SCHEMBL5229642 | 0.85 | DRD2 (0.42) | DRD4DRD3DRD2SMOMAPT | |
| SCHEMBL5228024 | 0.83 | HTR2C (0.42) | DRD4DRD3DRD2SMONR3C1 | |
| SCHEMBL5232217 | 0.82 | NR3C1 (0.40) | MAPTNR3C1 | |
| SCHEMBL5225265 | 0.79 | SMO (0.59) | DRD4DRD3DRD2SMOALDH1A1 | |
| SCHEMBL2761237 | 0.79 | SMO (0.43) | DRD4DRD3DRD2SMOALDH1A1 | |
| SCHEMBL5226797 | 0.78 | SMO (0.61) | SMOALDH1A1MAPTL3MBTL1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |