Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29478346 | 1.00 | LMNA (0.49) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL13528413 | 0.85 | MEN1 (0.44) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL4678132 | 0.83 | LMNA (0.40) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL15206387 | 0.83 | LMNA (0.40) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL30656292 | 0.83 | LMNA (0.40) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL29558416 | 0.81 | MEN1 (0.42) | LMNAALDH1A1CYP1A2MAPTNPC1 | |
| SCHEMBL5925649 | 0.81 | MEN1 (0.42) | LMNAALDH1A1CYP1A2MAPTNPC1 | |
| SCHEMBL13528418 | 0.81 | KDM4E (0.43) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL2843820 | 0.79 | ALDH1A1 (0.59) | LMNAALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL15395508 | 0.79 | ALDH1A1 (0.43) | LMNAALDH1A1CYP1A2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| US-20240025924-A1 | HETEROCYCLE SUBSTITUTED KETONE DERIVATIVE, AND COMPOSITION AND MEDICINAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20240025924-A1 | HETEROCYCLE SUBSTITUTED KETONE DERIVATIVE, AND COMPOSITION AND MEDICINAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| CN-114315796-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | disclosed |
| EP-3475273-B1 | 3-AMINO PYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH | BAYER CROPSCIENCE AG (DE) | 2021-02-24 | — | — | EP | disclosed |
| US-20200339548-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ADORX THERAPEUTICS LTD (GB) | 2020-10-29 | — | — | US | disclosed |
| US-20200339548-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ADORX THERAPEUTICS LTD (GB) | 2020-10-29 | — | — | US | disclosed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |
| US-10743540-B2 | 3-amino-1,2,4-triazine derivatives and their use for controlling undesired plant growth | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-08-18 | — | — | US | disclosed |
| US-20190230927-A1 | 3-AMINO-1,2,4-TRIAZINE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-08-01 | — | — | US | disclosed |
| EP-3475273-A1 | 3-AMINO-1,2,4-TRIAZINE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH | Bayer CropScience Aktiengesellschaft (DE) | 2019-05-01 | — | — | EP | disclosed |
| WO-2017220467-A1 | 3-AMINO-1,2,4-TRIAZINE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-12-28 | — | — | WO | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| EP-1575956-B1 | FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES | SYNGENTA LTD (GB) | 2007-03-28 | — | — | EP | disclosed |
| US-20060100203-A1 | Fungicides based on nitrogen-containing heterocycles | SYNGENTA CROP PROTECTION, INC. | 2006-05-11 | — | — | US | disclosed |
| EP-1575956-A1 | FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES | Syngenta Limited (GB) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004056829-A1 | FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES | SYNGENTA LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |
| WO-2002076984-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025924-A1 | HETEROCYCLE SUBSTITUTED KETONE DERIVATIVE, AND COMPOSITION AND MEDICINAL USE THEREOF | BCKDK, CYP11B2, HSD17B7 | LMNA 1849/4885ALDH1A1 348/4885CYP1A2 28/4885 |
| US-10743540-B2 | 3-amino-1,2,4-triazine derivatives and their use for controlling undesired plant growth | CYP4Z1, DAZAP1, AGXT | LMNA 4679/4885ALDH1A1 955/4885CYP1A2 151/4885 |
| US-20200339548-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | TYMP, TYMS, DPYD | LMNA 2831/4885ALDH1A1 465/4885CYP1A2 711/4885 |
| US-20060100203-A1 | Fungicides based on nitrogen-containing heterocycles | TACR3, NTSR1, CHRM1 | LMNA 3707/4885ALDH1A1 3737/4885CYP1A2 301/4885 |
| US-20190230927-A1 | 3-AMINO-1,2,4-TRIAZINE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH | CYP4Z1, DAZAP1, AGXT | LMNA 4679/4885ALDH1A1 955/4885CYP1A2 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.