Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 14/20 | 0.42 |
| ▸ | HTR2C | P28335 | 13/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230607 | 0.88 | DRD4 (0.46) | DRD2DRD4DRD3SMOTP53 | |
| SCHEMBL5227774 | 0.87 | DRD3 (0.45) | DRD2DRD4DRD3SMOTP53 | |
| SCHEMBL5230174 | 0.87 | DRD4 (0.46) | DRD2DRD4DRD3SMOTP53 | |
| SCHEMBL5227445 | 0.85 | DRD4 (0.46) | DRD2DRD4DRD3SMOMAPT | |
| SCHEMBL5226907 | 0.81 | DRD4 (0.43) | DRD2DRD4DRD3SMOTP53 | |
| SCHEMBL5228024 | 0.78 | HTR2C (0.42) | DRD2DRD4DRD3HTR2CSMO | |
| SCHEMBL5225265 | 0.75 | SMO (0.59) | DRD2DRD4DRD3SMOMAPT | |
| SCHEMBL5226797 | 0.74 | SMO (0.61) | SMOMAPT | |
| SCHEMBL5229662 | 0.74 | SMO (0.58) | DRD4SMOMAPT | |
| SCHEMBL5228219 | 0.73 | SMO (0.47) | DRD2DRD4DRD3SMOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |