Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236699 | 0.83 | CD274 (0.41) | HSD17B10USP2ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL5234836 | 0.83 | MEN1 (0.43) | HSD17B10USP2ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL5232177 | 0.82 | MAPT (0.42) | HSD17B10USP2ALDH1A1ALOX15DRD2 | |
| SCHEMBL5239486 | 0.82 | FGFR1 (0.41) | FGFR1FGFR2DHODHHSD17B10USP2 | |
| SCHEMBL5232288 | 0.81 | MAPT (0.41) | USP2ALDH1A1MAPK1ALOX15MAPT | |
| SCHEMBL5236779 | 0.81 | HDAC8 (0.39) | HSD17B10USP2ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL5236205 | 0.80 | RXRA (0.41) | DHODHALDH1A1FFAR2MAPTNPSR1 | |
| SCHEMBL5236546 | 0.80 | USP2 (0.46) | HSD17B10USP2ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL5240792 | 0.80 | NAAA (0.42) | FGFR1HSD17B10USP2ALDH1A1CYP3A4 | |
| SCHEMBL5233064 | 0.79 | L3MBTL1 (0.48) | ALDH1A1MAPK1MAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |