SCHEMBL523258

SCHEMBL523258

COC(=O)c1ccc(F)cc1F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.61
CES1 P23141 2/20 0.61
ALDH1A1 P00352 1/20 0.51
GAA P10253 1/20 0.51
MAPT P10636 3/20 0.50
KDM4E B2RXH2 1/20 0.50
SLC6A4 P31645 1/20 0.50
SLC6A3 Q01959 1/20 0.50
RAB9A P51151 3/20 0.49
NPC1 O15118 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
POLB P06746 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
ALPL P05186 1/20 0.49
LMNA P02545 1/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14012584 1.00 CES2 (0.61) CES2CES1ALDH1A1GAAMAPT
SCHEMBL30301996 0.86 SLC6A4 (0.51) CES2CES1ALDH1A1GAAMAPT
SCHEMBL2708451 0.86 SLC6A4 (0.51) CES2CES1ALDH1A1GAAMAPT
SCHEMBL2941745 0.85 SLC6A3 (0.57) CES2CES1ALDH1A1MAPTKDM4E
SCHEMBL30954392 0.85 CES2 (0.68) CES2CES1ALDH1A1GAAMAPT
SCHEMBL112046 0.84 CES2 (0.61) CES2CES1ALDH1A1MAPTKDM4E
SCHEMBL8359445 0.83 CES2 (0.65) CES2CES1ALDH1A1GAAMAPT
SCHEMBL5651048 0.83 CES2 (0.65) CES2CES1ALDH1A1GAAMAPT
SCHEMBL21274571 0.83 HPGD (0.52) CES2CES1ALDH1A1GAAKDM4E
SCHEMBL23607068 0.82 SLC6A4 (0.49) CES2CES1ALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 574 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4682148-A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES AbbVie Ireland Unlimited Company (IE) 2026-01-21 EP claimed
CN-120044163-A HPLC analysis and detection method for 2,4, 6-trifluoro benzoyl chloride and related substances thereof 复星万邦(江苏)医药集团有限公司 2025-05-27 CN claimed
EP-4474383-A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES AbbVie Ireland Unlimited Company (IE) 2024-12-11 EP claimed
CN-116505058-B Negative electrode interface modification method of solid-state lithium battery 河南师范大学 2024-02-13 CN claimed
CN-116505058-A Negative electrode interface modification method of solid-state lithium battery 河南师范大学 2023-07-28 CN claimed
CN-115306376-A Oil-gas well fracturing monitoring reagent, method and application thereof 中国石油天然气股份有限公司 2022-11-08 CN claimed
US-20220315555-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC. (US) 2022-10-06 US claimed
CN-114865080-A Lithium ion battery electrolyte and lithium ion battery 香河昆仑新能源材料股份有限公司 2022-08-05 CN claimed
US-20210221789-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC (US) 2021-07-22 US claimed
US-20200231566-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC (US) 2020-07-23 US claimed
EP-3656771-A1 PROCESS FOR THE PREPARATION OF A SYNTHETIC INTERMEDIATE FOR APOPTOSIS-INDUCING AGENTS AbbVie Ireland Unlimited Company (IE) 2020-05-27 EP claimed
US-20190119247-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC (US) 2019-04-25 US claimed
CN-107089981-A A kind of inhibitor Venetoclax of BCL 2 synthetic method 杭州科耀医药科技有限公司 2017-08-25 CN claimed
CN-106565734-A Psoralen ester derivatives and applications thereof 中国科学院新疆理化技术研究所 2017-04-19 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES UNIV YALE (US) 2026-04-30 US disclosed
US-20260116881-A1 KIF MODULATOR COMPOUNDS AND METHODS OF USE IAMBIC THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-5116844-A TRIAZOLE ANTIFUNGAL AGENTS PFIZER INC. (US) 1992-05-26 US disclosed
CN-1040795-A The preparation method of triazole species antimycotic agent PFIZER (US) 1990-03-28 CN disclosed
EP-0357241-A1 Triazole antifungal agents Pfizer Limited (GB) 1990-03-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260116881-A1 KIF MODULATOR COMPOUNDS AND METHODS OF USE KIF2C, KIF5B, KIF5C CES2 2605/4885CES1 1398/4885ALDH1A1 2556/4885
US-20210221789-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 CES2 4241/4885CES1 4153/4885ALDH1A1 4238/4885
US-20220315555-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 CES2 4241/4885CES1 4153/4885ALDH1A1 4238/4885
US-20190119247-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 CES2 4241/4885CES1 4153/4885ALDH1A1 4238/4885
US-20200231566-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 CES2 4241/4885CES1 4153/4885ALDH1A1 4238/4885
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES CRBN, VHL, ADRM1 CES2 3298/4885CES1 2403/4885ALDH1A1 2777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.