Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233779 | 0.90 | CA12 (0.41) | SLC6A7SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL5232329 | 0.89 | LMNA (0.48) | SMN1; SMN2MAPTLMNAPOLBHTT | |
| SCHEMBL5234118 | 0.87 | DHODH (0.41) | SLC6A7SMN1; SMN2MAPTHTTHPGD | |
| SCHEMBL5237326 | 0.86 | CA2 (0.43) | SMN1; SMN2MAPTLMNAHTTMEN1 | |
| SCHEMBL5236546 | 0.86 | USP2 (0.46) | SLC6A7SMN1; SMN2MAPTPOLBHPGD | |
| SCHEMBL5237020 | 0.86 | MGLL (0.47) | SLC6A7SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL5237974 | 0.84 | RXRA (0.44) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5238647 | 0.83 | USP2 (0.50) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5240792 | 0.83 | NAAA (0.42) | SMN1; SMN2NPC1MAPTLMNAHPGD | |
| SCHEMBL5232202 | 0.83 | RAB9A (0.40) | SMN1; SMN2NPC1MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |