Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234068 | 0.86 | DRD2 (0.45) | CYP3A4CYP2C9CYP2C19DRD2 | |
| SCHEMBL5237575 | 0.85 | RBP4 (0.43) | — | |
| SCHEMBL5239721 | 0.84 | TSHR (0.41) | ADRA1AADRA1BADRA1DDRD2 | |
| SCHEMBL5239761 | 0.82 | ADRA1A (0.41) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL5235916 | 0.81 | AR (0.40) | CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5237871 | 0.81 | DRD2 (0.40) | DRD2GAA | |
| SCHEMBL5238575 | 0.79 | CXCR3 (0.38) | ADRA1ADRD2 | |
| SCHEMBL5238192 | 0.78 | CYP2C19 (0.37) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5238831 | 0.77 | ALDH1A1 (0.43) | GAAL3MBTL1 | |
| SCHEMBL5235194 | 0.75 | PKM (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |