Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6022322 | 0.85 | ADRB2 (0.35) | OPRK1OPRM1OPRD1ADRB2ADORA3 | |
| SCHEMBL5281472 | 0.85 | TAAR1 (0.37) | CHRM1 | |
| SCHEMBL6027362 | 0.85 | TRPV1 (0.39) | OPRK1OPRM1OPRD1TRPV1SLC6A5 | |
| SCHEMBL5805321 | 0.84 | HDAC3 (0.40) | TRPV1SLC6A5 | |
| SCHEMBL6022468 | 0.83 | ADRB2 (0.43) | OPRK1TRPV1ADRB2ADORA3CHRM1 | |
| SCHEMBL6027475 | 0.83 | TRPV1 (0.37) | OPRK1OPRM1OPRD1TRPV1SLC6A5 | |
| SCHEMBL5243798 | 0.83 | FAAH (0.38) | TRPV1DRD1ADRA1ADRD3 | |
| SCHEMBL6027281 | 0.82 | PDCD1 (0.37) | SLC6A5 | |
| SCHEMBL6027383 | 0.81 | OPRM1 (0.36) | OPRK1OPRM1OPRD1SLC6A5SLC6A2 | |
| SCHEMBL6023018 | 0.81 | SLC6A5 (0.38) | OPRK1OPRM1OPRD1TRPV1SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856049-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006099031-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-09-21 | — | — | WO | claimed |