Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394087 | 0.80 | FABP4 (0.38) | FABP4KIF11L3MBTL1ESR1POLB | |
| SCHEMBL6672493 | 0.80 | FABP4 (0.38) | FABP4KIF11L3MBTL1ESR1POLB | |
| SCHEMBL4443952 | 0.75 | FABP4 (0.35) | FABP4KIF11L3MBTL1ESR1 | |
| SCHEMBL1801180 | 0.72 | TAS2R14 (0.30) | — | |
| SCHEMBL8691275 | 0.72 | AR (0.35) | FABP4KIF11ESR1POLBALDH1A1 | |
| SCHEMBL2597832 | 0.72 | FABP4 (0.53) | FABP4KIF11L3MBTL1ESR1POLB | |
| SCHEMBL7105084 | 0.69 | KIF11 (0.36) | KIF11ALDH1A1TSHRHSD11B1S1PR1 | |
| SCHEMBL28222652 | 0.69 | KIF11 (0.54) | FABP4KIF11L3MBTL1ESR1ALDH1A1 | |
| SCHEMBL1068717 | 0.69 | CA2 (0.34) | L3MBTL1POLBALDH1A1HSD11B1LMNA | |
| SCHEMBL10768905 | 0.68 | KIF11 (0.35) | KIF11ALDH1A1TSHRHSD11B1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598483-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |