Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 6/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265199 | 0.88 | GAA (0.47) | ALDH1A1KDM4EMETAP2KEAP1NFE2L2 | |
| SCHEMBL5268738 | 0.88 | METAP2 (0.44) | ALDH1A1KDM4EMETAP2KEAP1NFE2L2 | |
| SCHEMBL5266751 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KDM4EMETAP2KMT2ALMNA | |
| SCHEMBL5318573 | 0.87 | SLC40A1 (0.49) | ALDH1A1KDM4EMETAP2KMT2ALMNA | |
| SCHEMBL5270408 | 0.86 | LMNA (0.49) | ALDH1A1KEAP1NFE2L2LMNAHTT | |
| SCHEMBL5269858 | 0.85 | KMT2A (0.45) | ALDH1A1KDM4EMETAP2KMT2ALMNA | |
| SCHEMBL4284633 | 0.85 | KMT2A (0.49) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL5271482 | 0.84 | MCL1 (0.42) | ALDH1A1KDM4EMETAP2KMT2APOLB | |
| SCHEMBL5269774 | 0.83 | KDM4E (0.55) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL5272339 | 0.81 | LMNA (0.54) | ALDH1A1KMT2ALMNAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |