Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266131 | 0.92 | LMNA (0.50) | ALDH1A1HPGDCYP1A2SMN1; SMN2POLB | |
| SCHEMBL5271746 | 0.90 | ALDH1A1 (0.50) | TP53ALDH1A1HPGDHTTKMT2A | |
| SCHEMBL2801723 | 0.87 | KMT2A (0.54) | MDM4TP53HPGDCYP1A2HTT | |
| SCHEMBL5266785 | 0.85 | F10 (0.54) | TP53ALDH1A1HPGDCYP1A2SMN1; SMN2 | |
| SCHEMBL5273753 | 0.84 | MLYCD (0.49) | HTTKMT2AMAPT | |
| SCHEMBL5269232 | 0.83 | CLK1 (0.49) | POLBKMT2AMEN1PKM | |
| SCHEMBL5265834 | 0.83 | SIRT1 (0.53) | HTTPOLBKMT2AMEN1ADORA3 | |
| SCHEMBL4287582 | 0.83 | KDM4E (0.50) | TP53ALDH1A1CYP1A2SMN1; SMN2HTT | |
| SCHEMBL5272554 | 0.83 | KMT2A (0.47) | ALDH1A1CYP1A2SMN1; SMN2HTTPOLB | |
| SCHEMBL4286877 | 0.81 | PAX8 (0.56) | MDM4TP53ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |