Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16956724 | 0.92 | GABRA1 (0.39) | HDAC4HDAC2HDAC8GABRA1GABRB2 | |
| SCHEMBL9244494 | 0.83 | HDAC4 (0.42) | HDAC4HDAC2HDAC8GABRA1GABRB2 | |
| SCHEMBL7721762 | 0.79 | HDAC4 (0.37) | HDAC4HDAC2HDAC8GABRA1GABRB2 | |
| SCHEMBL2530090 | 0.79 | HDAC4 (0.39) | HDAC4HDAC2HDAC8GABRA1GABRB2 | |
| SCHEMBL7531576 | 0.78 | HDAC4 (0.50) | HDAC4HDAC2HDAC8CA1CA2 | |
| SCHEMBL6004412 | 0.78 | HDAC4 (0.50) | HDAC4HDAC2HDAC8CA1CA2 | |
| SCHEMBL3169205 | 0.76 | HDAC4 (0.52) | HDAC4HDAC2HDAC8CA1CA2 | |
| SCHEMBL16951488 | 0.74 | GABRA1 (0.39) | GABRA1GABRB2TSHRFAAHCA1 | |
| SCHEMBL7869684 | 0.74 | TRPA1 (0.48) | HDAC4HDAC2HDAC8CA1CA2 | |
| SCHEMBL16959127 | 0.73 | HTR1A (0.34) | HDAC4HDAC2HDAC8GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851197-A2 | PHENYLAZETIDINONE DERIVATIVES | Microbia, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006102674-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
| WO-2006086562-A2 | PHENYLAZETIDINONE DERIVATIVES | MICROBIA, INC. (US) | 2006-08-17 | — | — | WO | disclosed |