Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12840855 | 0.84 | THRB (0.38) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL21635498 | 0.84 | ALDH1A1 (0.50) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL10154713 | 0.84 | THRB (0.38) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL12136032 | 0.84 | RAPGEF4 (0.44) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL12852152 | 0.84 | RAPGEF4 (0.44) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL21812073 | 0.84 | THRB (0.38) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL12229096 | 0.82 | MAPT (0.41) | THRBMAPTPOLBCYP3A4TSHR | |
| SCHEMBL14039103 | 0.80 | THRB (0.40) | THRBRAPGEF4HTTNPSR1MAPT | |
| SCHEMBL16236818 | 0.80 | POLB (0.42) | THRBRAPGEF4MAPTPOLBSMN1; SMN2 | |
| SCHEMBL4740356 | 0.80 | THRB (0.64) | THRBRAPGEF4HTTNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046698-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| CN-107088414-B | A kind of N- ethylization catalyst and its preparing the application in N-ethylaniline derivative | 湖北新德晟材料科技有限公司 | 2019-09-10 | — | — | CN | disclosed |
| US-20190031664-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-01-31 | — | — | US | disclosed |
| CN-107088414-A | A kind of N ethylizations catalyst and its application in N MEA derivatives are prepared | 武汉德晟生化科技有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-103975003-B | Carbon fiber forming blank, moulding material and carbon fibre reinforced composite | 东丽株式会社 | 2017-07-28 | — | — | CN | disclosed |
| US-20160096819-A1 | PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF | BASF SE (DE) | 2016-04-07 | — | — | US | disclosed |
| EP-2997020-A1 | PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF | BASF SE (DE) | 2016-03-23 | — | — | EP | disclosed |
| US-20160045528-A1 | COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS | ALIOS BIOPHARMA, INC. | 2016-02-18 | — | — | US | disclosed |
| US-20160045528-A1 | COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS | ALIOS BIOPHARMA, INC. | 2016-02-18 | — | — | US | disclosed |
| WO-2016022464-A1 | COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS | ALIOS BIOPHARMA, INC. (US) | 2016-02-11 | — | — | WO | disclosed |
| EP-0350166-B1 | Polymer compositions | NIPPON OIL CO LTD (JP) | 1994-03-23 | — | — | EP | disclosed |
| US-5208274-A | Mixing with magnesium oxide or hydroxide and azelaic acid, catechol, glyoxal, or salicylic acid | BORDEN, INC. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5180795-A | Anilines, Salicylamide, Sulfanilic Acid, Anilinesulfonic Acid | BORDEN, INC. (US) | 1993-01-19 | — | — | US | disclosed |
| US-5120472-A | POLYMER COMPOSITIONS | NIPPON OIL COMPANY (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0469785-A2 | Retarders for curing/hardening resole resins | Borden, Inc. (US) | 1992-02-05 | — | — | EP | disclosed |
| EP-0350166-A2 | Polymer compositions | NIPPON OIL CO., LTD. (JP) | 1990-01-10 | — | — | EP | disclosed |
| EP-0035355-B1 | MODIFIED ALUMINIUM HYDRIDES, THEIR PREPARATION AND THEIR USE IN REDUCING ACETYLNAPHTHALENE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-05-09 | — | — | EP | disclosed |
| US-4418218-A | REDUCTION WITH LITHIUM ALUMINUM HYDRIDE AND N-SUBSTITUTED EPHEDRINE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-11-29 | — | — | US | disclosed |
| US-4338255-A | Modified lithium aluminum hydrides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-07-06 | — | — | US | disclosed |
| EP-0035355-A2 | Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046698-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | THRB 758/4885RAPGEF4 4132/4885HTT 1087/4885 |
| US-20190031664-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | THRB 758/4885RAPGEF4 4132/4885HTT 1087/4885 |
| US-20160045528-A1 | COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS | MAVS, EIF2AK2, SARS1 | THRB 1940/4885RAPGEF4 2492/4885HTT 4869/4885 |
| US-20160096819-A1 | PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF | CA3, CA2, CA1 | THRB 2898/4885RAPGEF4 1530/4885HTT 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.