Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528272 | 0.91 | MAPT (0.45) | MAPTALDH1A1HTTNPSR1GAA | |
| SCHEMBL528274 | 0.89 | L3MBTL1 (0.47) | MAPTALDH1A1HTTNPC1POLB | |
| SCHEMBL528938 | 0.89 | ALDH1A1 (0.59) | MAPTALDH1A1HTTNPSR1GAA | |
| SCHEMBL529461 | 0.86 | MAPT (0.50) | MAPTALDH1A1HTTNPC1LMNA | |
| SCHEMBL527889 | 0.85 | ALDH1A1 (0.58) | MAPTALDH1A1HTTNPSR1GAA | |
| SCHEMBL529438 | 0.82 | MAPT (0.54) | MAPTALDH1A1NPSR1NPC1POLB | |
| SCHEMBL528572 | 0.80 | RXFP1 (0.48) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL528332 | 0.80 | ALDH1A1 (0.51) | MAPTALDH1A1HTTNPSR1GAA | |
| SCHEMBL528277 | 0.79 | MAPT (0.62) | MAPTALDH1A1HTTNPSR1GAA | |
| SCHEMBL529458 | 0.79 | MAPT (0.52) | MAPTALDH1A1HTTNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |