SCHEMBL188668

SCHEMBL188668

O=C(O)CNc1ccc(F)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50
HSD17B14 Q9BPX1 1/20 0.49
HPGD P15428 1/20 0.45
TSHR P16473 1/20 0.45
ALDH1A1 P00352 3/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
MAPT P10636 1/20 0.44
KDM4E B2RXH2 2/20 0.43
GLA P06280 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
TP53 P04637 1/20 0.43
GAA P10253 1/20 0.43
GFER P55789 1/20 0.43
HSD17B10 Q99714 1/20 0.43
RECQL P46063 1/20 0.42
NAMPT P43490 1/20 0.42
ALDH3A1 P30838 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11532312 0.85 HSD17B14 (0.50) HSD17B14ALDH1A1MEN1KMT2AMAPT
SCHEMBL14053068 0.84 ALDH1A1 (0.48) RAB9ANPC1HSD17B14ALDH1A1MEN1
SCHEMBL29894695 0.84 FABP4 (0.56) RAB9ANPC1TSHRALDH1A1MEN1
SCHEMBL1434153 0.84 FFAR1 (0.46) HSD17B14TSHRALDH1A1MEN1KMT2A
SCHEMBL2728813 0.84 FABP4 (0.56) RAB9ANPC1TSHRALDH1A1MEN1
SCHEMBL29499460 0.84 FFAR1 (0.46) HSD17B14TSHRALDH1A1MEN1KMT2A
SCHEMBL14053181 0.84 ALDH1A1 (0.62) RAB9ANPC1HSD17B14ALDH1A1MEN1
SCHEMBL8486763 0.83 ALDH1A1 (0.55) RAB9ANPC1HPGDTSHRALDH1A1
SCHEMBL28304775 0.81 RAB9A (0.42) RAB9ANPC1HPGDTSHRALDH1A1
SCHEMBL30366824 0.80 ALDH1A1 (0.48) RAB9ANPC1HPGDTSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4687443-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE Genepep (FR) 2026-02-11 EP disclosed
WO-2024208878-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE GENEPEP (FR) 2024-10-10 WO disclosed
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2023-12-28 US disclosed
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer Karoyan, Philippe (FR) 2023-09-19 US disclosed
EP-3454879-B1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER INST NAT SANTE RECH MED (FR) 2021-12-22 EP disclosed
US-20210121465-A1 FERROCHELATASE INHIBITORS AND METHODS OF USE GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2021-04-29 US disclosed
EP-3787630-A1 FERROCHELATASE INHIBITORS AND METHODS OF USE Indiana University Research and Technology Corporation (US) 2021-03-10 EP disclosed
CN-107406373-B Boron-containing diacylhydrazine compounds 英特瑞克斯顿股份有限公司 2020-04-28 CN disclosed
EP-3194359-B1 BORON-CONTAINING DIACYLHYDRAZINE COMPOUNDS INTREXON CORP (US) 2020-04-08 EP disclosed
US-10570158-B2 Boron-containing diacylhydrazine compounds INTREXON CORPORATION (US) 2020-02-25 US disclosed
EP-1076563-A4 DIPEPTIDE CASPASE INHIBITORS AND THE USE THEREOF CYTOVIA INC (US) 2003-04-23 EP disclosed
US-20020155455-A1 Highly homogeneous molecular markers for electrophoresis INVITROGEN CORPORATION 2002-10-24 US disclosed
EP-1220869-A1 CASPASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY AND RADIATION THERAPY INDUCED CELL DEATH Cytovia, Inc. (US) 2002-07-10 EP disclosed
WO-2002013848-A1 HIGHLY HOMOGENEOUS MOLECULAR MARKERS FOR ELECTROPHORESIS INVITROGEN CORPORATION (US) 2002-02-21 WO disclosed
CN-1297354-A Dipeptide caspase inhibitors and use thereof CYTOVIA INC (US) 2001-05-30 CN disclosed
WO-2001027140-A1 CASPASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY AND RADIATION THERAPY INDUCED CELL DEATH CYTOVIA, INC. (US) 2001-04-19 WO disclosed
EP-1076563-A1 DIPEPTIDE CASPASE INHIBITORS AND THE USE THEREOF Cytovia, Inc. (US) 2001-02-21 EP disclosed
US-6153591-A PROTECTING NERVOUS SYSTEM FOLLOWING FOCAL ISCHEMIA AND GLOBAL ISCHEMIA; ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, PRION DISEASES, PARKINSON'S DISEASE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, ALOPACIA, RHEUMATOID ARTHRITIS CYTOVIA, INC. (US) 2000-11-28 US disclosed
WO-1999047154-A1 DIPEPTIDE CASPASE INHIBITORS AND THE USE THEREOF CYTOVIA, INC. (US) 1999-09-23 WO disclosed
WO-1999025345-A1 ALPHA-1A ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1999-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121465-A1 FERROCHELATASE INHIBITORS AND METHODS OF USE FECH, SLC40A1, TPI1 RAB9A 2556/4885NPC1 572/4885HSD17B14 108/4885
US-10570158-B2 Boron-containing diacylhydrazine compounds BRDT, CD22, BCR RAB9A 2417/4885NPC1 2388/4885HSD17B14 652/4885
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer VIP, RNASE1, ABCB11 RAB9A 2903/4885NPC1 469/4885HSD17B14 977/4885
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER VIP, RNASE1, ABCB11 RAB9A 2903/4885NPC1 469/4885HSD17B14 977/4885
US-20020155455-A1 Highly homogeneous molecular markers for electrophoresis CD44, HLA-C, HLA-A RAB9A 3935/4885NPC1 4438/4885HSD17B14 1601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.