Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | PDXK | O00764 | 1/20 | 0.33 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5420558 | 0.86 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL4576389 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL4577077 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL4576784 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL12676992 | 0.70 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10PDE4A | |
| SCHEMBL5427118 | 0.68 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL5420563 | 0.68 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| Pyridoxine SCHEMBL43879 | 0.68 | KDM4E (0.83) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| Pyridoxine SCHEMBL29004449 | 0.68 | KDM4E (0.83) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL4577063 | 0.67 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167411-A1 | Compositions for treating angina | MEDICURE INTERNATIONAL INC. (BB) | 2007-07-19 | — | — | US | disclosed |
| EP-1796685-A1 | PYRIDOXAL-5´-PHOSPHATE AND RELATED COMPOUNDS IN COMBINATION WITH THERAPEUTIC CADIOVASCULAR COMPOUNDS FOR TREATING ANGINA. | Medicure International Inc. (CA) | 2007-06-20 | — | — | EP | disclosed |
| US-20070032456-A1 | Modulation of cell death | MEDICURE INC. (CA) | 2007-02-08 | — | — | US | disclosed |
| US-7105673-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2006-09-12 | — | — | US | disclosed |
| WO-2006058411-A1 | PYRIDOXAL-5´-PHOSPHATE AND RELATED COMPOUNDS IN COMBINATION WITH THERAPEUTIC CADIOVASCULAR COMPOUNDS FOR TREATING ANGINA. | MEDICURE INTERNATIONAL INC. (CA) | 2006-06-08 | — | — | WO | disclosed |
| EP-1531157-A1 | Cardioprotective phosphonates | Medicure International Inc. (BB) | 2005-05-18 | — | — | EP | disclosed |
| US-6867215-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2005-03-15 | — | — | US | disclosed |
| US-6861439-B2 | Treatment of cerebrovascular disease | MEDICURE INTERNATIONAL, INC. (BB) | 2005-03-01 | — | — | US | disclosed |
| US-6780997-B2 | SUCH AS DIBENZYL(A,3-O-ISOPROPYLIDIENE-3-HYDROXY-4-HYDROXYMETHYL-2-METHYL-5-PYRIDYL) HYDROXYMETHYLPHOSPHONATE WHICH FUNCTIONS LIKE PYRIDOXAL-5'-PHOSPHATE IN VIVO; DRUG SCREENING; ANTIDIABETIC AGENTS | MEDICURE INTERNATIONAL INC. (BB) | 2004-08-24 | — | — | US | disclosed |
| US-20040121988-A1 | Treatment of cerebrovascular disease | MEDICURE INTERNATIONAL INC. (BB) | 2004-06-24 | — | — | US | disclosed |
| US-6667315-B2 | Pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) | MEDICURE INTERNATIONAL INC. (BA) | 2003-12-23 | — | — | US | disclosed |
| US-20030181422-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-09-25 | — | — | US | disclosed |
| US-6605612-B2 | Derivatives of 5-pyridylalkylphosphonates and 5-pyridylalkylmalonates useful drugs for treatment of cardiovascular related diseases and diabetes mellitus related diseases | MEDICURE INTERNATIONAL INC. (BB) | 2003-08-12 | — | — | US | disclosed |
| US-20030120074-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-26 | — | — | US | disclosed |
| US-20030114677-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-19 | — | — | US | disclosed |
| US-20030114678-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-19 | — | — | US | disclosed |
| EP-1268498-A1 | CARDIOPROTECTIVE PHOSPHONATES AND MALONATES | Medicure International Inc. (BB) | 2003-01-02 | — | — | EP | disclosed |
| US-20020010158-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (CA) | 2002-01-24 | — | — | US | disclosed |
| WO-2001064692-A1 | CARDIOPROTECTIVE PHOSPHONATES AND MALONATES | MEDICURE INTERNATIONAL INC. (BB) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114677-A1 | Cardioprotective phosphonates and malonates | PDXK, PHOSPHO1, PNPO | KDM4E 519/4885ALDH1A1 2080/4885HPGD 403/4885 |
| US-20030181422-A1 | Cardioprotective phosphonates and malonates | PDXK, PHOSPHO1, PNPO | KDM4E 519/4885ALDH1A1 2080/4885HPGD 403/4885 |
| US-20070167411-A1 | Compositions for treating angina | PNPO, PYGM, PLPBP | KDM4E 2123/4885ALDH1A1 1367/4885HPGD 153/4885 |
| US-20020010158-A1 | Cardioprotective phosphonates and malonates | PDXK, PHOSPHO1, PNPO | KDM4E 519/4885ALDH1A1 2080/4885HPGD 403/4885 |
| US-20040121988-A1 | Treatment of cerebrovascular disease | PNPO, PLPBP, PDXK | KDM4E 1621/4885ALDH1A1 1627/4885HPGD 242/4885 |
| US-20030120074-A1 | Cardioprotective phosphonates and malonates | PDXK, PHOSPHO1, PNPO | KDM4E 519/4885ALDH1A1 2080/4885HPGD 403/4885 |
| US-20070032456-A1 | Modulation of cell death | CASP6, CASP3, CASP5 | KDM4E 1592/4885ALDH1A1 3492/4885HPGD 308/4885 |
| US-20030114678-A1 | Cardioprotective phosphonates and malonates | PDXK, PHOSPHO1, PNPO | KDM4E 519/4885ALDH1A1 2080/4885HPGD 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.