Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307374 | 0.91 | SLC6A4 (0.55) | DRD2DRD4DRD3ADRA1AADRA1D | |
| SCHEMBL5302822 | 0.91 | ADRA1A (0.65) | DRD2DRD4DRD3ADRA1AADRA1D | |
| SCHEMBL5325863 | 0.90 | DRD2 (0.59) | DRD2DRD4DRD3ADRA1AADRA1D | |
| SCHEMBL5310370 | 0.87 | ADRA1A (0.50) | DRD2DRD3ADRA1AADRA1DADRA1B | |
| SCHEMBL5329403 | 0.81 | ADRA1A (0.65) | DRD2DRD4DRD3ADRA1AADRA1D | |
| SCHEMBL5328407 | 0.80 | SLC6A4 (0.55) | DRD2DRD4DRD3ADRA1AADRA1D | |
| SCHEMBL5306802 | 0.77 | ADRA1A (0.49) | DRD2DRD3ADRA1AADRA1DADRA1B | |
| SCHEMBL9652838 | 0.77 | DRD2 (0.69) | DRD2DRD4DRD3ADRA1AHTR1A | |
| SCHEMBL7703653 | 0.75 | DRD2 (0.83) | DRD2DRD4DRD3ADRA1AADRA1D | |
| SCHEMBL8446460 | 0.74 | DRD2 (0.85) | DRD2DRD4ADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007029156-A2 | ISOINDOLEDIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | claimed |
| WO-2007029156-A2 | ISOINDOLEDIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | disclosed |