Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL324010 | 0.78 | KMT2A (0.49) | LMNAMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL38652062 | 0.78 | KMT2A (0.49) | LMNAMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL3537897 | 0.77 | LPO (0.55) | LMNAMAPK1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5138866 | 0.77 | LMNA (0.42) | CSF1RNPC1RAB9ALMNAMEN1 | |
| SCHEMBL5345269 | 0.76 | CSF1R (0.39) | CSF1RNPC1RAB9ALMNAMEN1 | |
| SCHEMBL28251110 | 0.76 | LMNA (0.47) | CSF1RNPC1RAB9ALMNAKDM4E | |
| SCHEMBL5328756 | 0.76 | MAPK14 (0.39) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6222891 | 0.75 | LMNA (0.63) | NPC1RAB9ALMNAMAPK1MEN1 | |
| SCHEMBL1362776 | 0.74 | MTNR1A (0.44) | — | |
| SCHEMBL30828413 | 0.73 | ATM (0.57) | LMNAMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |