Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328756 | 0.82 | MAPK14 (0.39) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL5322845 | 0.76 | CSF1R (0.55) | CSF1RKDM4EALDH1A1LMNATSHR | |
| SCHEMBL411641 | 0.70 | FGFR1 (0.51) | CSF1RFLT1KDRPLK1NPSR1 | |
| SCHEMBL1362776 | 0.68 | MTNR1A (0.44) | PTK2SLC22A12 | |
| SCHEMBL28251110 | 0.67 | LMNA (0.47) | CSF1RKDM4ELMNANPC1RAB9A | |
| SCHEMBL3537897 | 0.67 | LPO (0.55) | KDM4EUSP2ALDH1A1LMNATSHR | |
| SCHEMBL9278020 | 0.65 | TP53 (0.45) | KDM4EALDH1A1LMNAMEN1NPC1 | |
| SCHEMBL414642 | 0.65 | CTSV (0.39) | CSF1RFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL5345274 | 0.65 | KDR (0.42) | CSF1RPDE10AFLT1KDRPLK1 | |
| SCHEMBL38652180 | 0.65 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |