Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491066 | 0.80 | KDM4E (0.32) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL726410 | 0.77 | KDM4E (0.33) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2345893 | 0.77 | PTGS2 (0.33) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL315821 | 0.76 | ACHE (0.39) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8682848 | 0.74 | ALDH1A1 (0.38) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL13835731 | 0.74 | CA2 (0.35) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2137796 | 0.72 | — | — | |
| SCHEMBL455383 | 0.72 | — | — | |
| SCHEMBL9873091 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL721990 | 0.70 | MAOA (0.32) | KDM4EALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |