Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IL6 | P05231 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753094 | 0.78 | GNRHR (0.41) | KIF11TLR7GNRHRTDP1BRD4 | |
| SCHEMBL4753082 | 0.78 | TLR7 (0.41) | KIF11TLR7GNRHRL3MBTL1PAX8 | |
| SCHEMBL5248653 | 0.78 | KIF11 (0.42) | KIF11TLR7SIGMAR1GNRHRBRD4 | |
| SCHEMBL5250052 | 0.76 | KIF11 (0.40) | KIF11TLR7SIGMAR1GNRHRPCSK9 | |
| SCHEMBL4752600 | 0.75 | KIF11 (0.42) | KIF11TLR7L3MBTL1 | |
| SCHEMBL5233038 | 0.70 | SLC26A6 (0.39) | KIF11GNRHRBRD4POLBMAPT | |
| SCHEMBL4363435 | 0.68 | PCSK9 (0.42) | KIF11GNRHRPCSK9IDO1BRD4 | |
| SCHEMBL5918503 | 0.67 | KIF11 (0.38) | KIF11TLR7SIGMAR1L3MBTL1PAX8 | |
| SCHEMBL5754463 | 0.66 | SYK (0.43) | KIF11L3MBTL1BRD4POLBMAPT | |
| SCHEMBL4368388 | 0.65 | CRHBP (0.43) | PCSK9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781674-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTION OF CANCER | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018628-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTI ON OF CANCER | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |